Protriptyline hydrochloride

CAS No. 1225-55-4

Protriptyline hydrochloride ( —— )

Catalog No. M10865 CAS No. 1225-55-4

Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA).

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 38 In Stock
25MG 82 In Stock
50MG 140 In Stock
100MG Get Quote In Stock
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Biological Information

  • Product Name
    Protriptyline hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA).
  • Description
    Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    Sert (Sodium-dependent)
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1225-55-4
  • Formula Weight
    299.84
  • Molecular Formula
    C19H21N·HCl
  • Purity
    >98%(HPLC)
  • Solubility
    Soluble in DMSO
  • SMILES
    Cl.CNCCCC1C2=CC=CC=C2C=CC2=CC=CC=C12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.McDougle CJ, et al. Mol Psychiatry. 1998 May;3(3):270-3.
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