Protriptyline hydrochloride
CAS No. 1225-55-4
Protriptyline hydrochloride ( —— )
Catalog No. M10865 CAS No. 1225-55-4
Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA).
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
10MG | 38 | In Stock |
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25MG | 82 | In Stock |
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50MG | 140 | In Stock |
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100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameProtriptyline hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionProtriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA).
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DescriptionProtriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorSert (Sodium-dependent)
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1225-55-4
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Formula Weight299.84
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Molecular FormulaC19H21N·HCl
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Purity>98%(HPLC)
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SolubilitySoluble in DMSO
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SMILESCl.CNCCCC1C2=CC=CC=C2C=CC2=CC=CC=C12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.McDougle CJ, et al. Mol Psychiatry. 1998 May;3(3):270-3.
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